A 29-year-old Kidderminster man has been charged with criminal transmission of HIV.
Luke Davis, of George Street, is due to go on trial at Worcester Crown Court.
The charge follows an investigation by West Mercia Police and relates to one victim.
Detectives want to hear from anyone who is concerned they have received sexual services offered via various social media platforms, possibly under an alias, such as Naomi, a 26-year-old bisexual.
They also want to talk to people who have visited adult parties in Lyndholme Road in Kidderminster.
Davis appeared at Worcester Crown Court on Tuesday July 11 and is next due to appear for a plea and case management hearing on November 24.
Superintendent Mel Paley said: “We acknowledge people may be concerned about this case.
“In publicising it we have taken careful consideration to ensure the right balance between protection of the public and protection of the defendant’s rights to a fair trial.
“If you are concerned there are several ways you can contact the investigation team or seek support.”
Police said in a statement that "it is important to recognise that as criminal proceedings against Mr Davis are active, he is presumed innocent of this charge until proven guilty and has the right to a fair trial.
"It is important that the public refrain from speculation or social media commentary that could prejudice the case."
Davis pleaded not guilty at Worcester Magistrates Court on Tuesday June 6.
Anyone with concerns can contact the police via 101, request West Mercia Police and then tell the call handler they wish to make a report in relation to Operation Origin or email OpOrigin@westmercia.police.uk.
Anyone who may have been affected but is not in a place where they can talk to people about it at the moment can request that a third-party report is made to West Mercia Police via a sexual health service provider.
They should include details you are prepared to share and that the case relates to Operation Origin.
This will allow the police investigation team to be aware of the potential number of people affected.
People can ring without prejudice and their personal circumstances will be respected.
All reports to the police are confidential and people do not have to give their details if they feel unable to.
Although the risk of transmission is low, anyone concerned should get tested for HIV and other sexually transmitted infections.
Confidential testing will help people receive effective treatments for HIV or any STI.
Anyone can book a test through a local sexual health clinic.
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